If there is no afterlife and this life is all we have, that doesn't mean it makes more sense that an afterlife is real, just because many people would find that more comforting or desirable. I haven't seen any reliable evidence that there is an afterlife, and that's why I don't believe there is one. And if anything, that makes this life even more special, because that means it is the only life we have so we have to make the most of it and do what we can to make the world a better place.
As far as a God creating life, I don't see any evidence for that either. And then you would have to try to figure out where that God came from. If you say God has always existed, then you have no way to demonstrate that. People just use God is an easy answer for stuff they don't know because it makes them feel like they have solved the mystery.