Damn, you beat me to it, but that's exactly what I think of everytime. Sometimes I'll look at a picture or video of Biden and think "Damn, what the f**k is up with his eyes?"
I'm not a doctor, but I wonder if some of the psycotropic drugs that his handlers are pumping him up on are giving him unintended side effects (eyes, grin, whispering, flying off of the handle, etc.)