It's not that you disagree. It's that you deny scientific facts, because you don't like them. Your problem, not theirs. And no, that you are are either XX or XY is not entirely true either. And trust me, I've had the topic of genetics discussed in my training, so the fact that sometimes you can even get into a kind of XXY or XYY situation, causing females with more male properties and vice versa was one of the first things my teacher noted, and he said that this was just one of the many issues you'll be dealing with when it comes to genetics and the entire science behind sex and sexuality. Is there something "wrong" with them? I guess that depends on which perspective you look at it, but "wrong" or not wrong, it's not they are confused about themselves. It's rather that we are confused about them, treating them with a xenophobic approach, and wanting them to be "normal", while they are already are "normal" from their own point of view. And who are we to decide what is "normal", anyway? And when people around you don't accept you for who and what you are THAT is what causes inferiority complexes. But if somebody has no legs, is there something "wrong" with him? You can say so, as that is not how it "should" be, but yet they too are normal human beings, quite often suffering as the world has not been well set-up for people who move around in a wheelchair, which can also sometimes cause mental issues. There is no greater pain than not being taken for who and what you truly are, and that alone can be one of the biggest issue you can face, no matter what the reason in. Either it be your sexuality, skin color, religion, any impairments or whatever. "Wrong body" is how some transgenders actually experience it themselves (not all of them), the body in which they feel its not the body they wanted. And is also why some of them undergo surgery to "correct" that. Things being either 0 or 1 only, works in the computer, but biology (which includes sexuality) never works in two options alone, even when it looks that way. And most women act differently than most men (that's a fact), but some women have some 'male behavior' and vice versa, and sometimes this goes into a "further level" in which come to, well this... Disagreement and refusing to acknowledge facts are two different things. No, I ain't a transgender myself, but I've met a few, not to mention that I know the drill about not being accepted for what you are, and that is the suffering I noticed in them most.