I don't draw the line where people claim other people "playing god" unless the person doing it actually claims to be godlike themselves (for example, a person who just invented a viable way to harvest antimatter could say "Hahaha, tremble before my ability to create massive amounts of explosive substance, mortals!!! I am a god!!! A god, I say!!!", and it would be playing god, whereas a scientist who thanked god for giving him the knowledge to alter a plant's DNA to grow massive amounts of food in third world countries would not be playing god. In my opinion, "playing god" is all about the arrogance that comes with the technology, not the technology itself.
For example, all of the things you just listed (except sentient technology) actually have many possible ways to help the human race, such as:
Cloning - Bringing species back from the brink of extinction (both human-induced and non-human-induced), Helping infertile and homosexual couples have children, cloning specific body parts for organ donation (yes, they will eventually be able to do that), etc.,
Artificial Immortality - Kind of speaks for itself. Humans already live much longer than they did when we first showed up on this planet, so why not cure old age (although we'll probably still die in other ways, and will definitely be destroyed when the universe ends)? We'd probably need to work on the technology for colonization of other planets or planetoids like mars or the moon before that, though, to avoid overpopulation.
Genetic Engineering - Come on, we can do loads of things with genetic engineering. We can make weedkiller-resistant crops that produce even more food and can grow in harsher environments. We can remove genetic defects, create new lifeforms more suited for newly-colonized planets, and prevent harmful mutations. Hell, we could probably eventually use it to cure harmful mutations that already exist, though we'd have to wait until the old cells died and were replaced by new, modified cells.
New technology is exiting, and I'm still bummed that we got cellphones that spy on you instead of spaceships to mars in the new millennium.
But hey, I'm just a shithead transhumanist commie slave of the satanic agenda (that was sarcastic), so feel free to ignore my opinion.