tl;dr The EC is an electoral handicap that allows the less-popular candidate to win some of the time. The fancy poli-sci term for this is "counter-majoritarian."
Longer story: In my opinion, the EC is a recipe for democratic apathy, divisiveness, unsatisfactory government, and a discontented population, as we saw over the past 4 years of Trump's presidency frankly, and arguably during G.W. Bush's term as well.
1. Why apathy? While some states are swing states, many states are firmly "red state" or "blue state" and for those who live there, having your vote for President "not really matter" as a result is a motivation to not turn out and vote at all.
2. Why divisiveness? There's little incentive to compromise and appeal to most of the country when presidential candidates know most states they need are already in their bag, and they don't have to work for them.
3. Why unsatisfactory government? The EC gives large-sized swing states like Florida and Pennsylvania undue influence on our nation's politics, to the detriment of states that aren't "strategic." This distorts our nation's policies and presidents' priorities.
4. Why a discontented population? The widening gap between the popular vote and Electoral College results means that on occasions when the "loser wins," millions more people will be dissatisfied with the outcome than otherwise.
Amending the Constitution requires a large bipartisan majority and it's doubtful Republicans will ever agree to reform it, because currently the EC seems to be their only shot at winning the Presidency.
However, let's just point out a few more things:
1. Every other elected position in the entire United States is selected by popular vote. This includes U.S. Senators, which were not originally chosen by popular vote but were made subject to the votes of the people via the 17th Amendment. https://en.wikipedia.org/wiki/Seventeenth_Amendment_to_the_United_States_Constitution
2. Every other democracy in the world with a presidential system chooses the president by national popular vote. In no other country can the "loser" win.
3. While abolishing the Electoral College is a pipe dream in our current political climate, the Electoral College does not actually need to be abolished to remove some of its pernicious effects; we just need to abolish the "winner-take-all" aspect and allow states to apportion their EC votes in a manner consistent with how their people actually voted. That would help.