I would never defend Epstein.
As far as him and Trump being good friends, they knew each from being in the same social circles, but Trump barred him from Mar-a-largo. Trump also provided evidence against Epstein in his first conviction, so I don't know how good of friends they were.
Yes, the photo does mean something. It is photographic proof that Creepy Joe acts inappropriately around women and especially children.
Now that more is coming out from Hunters laptop, things could get sticky for the Big Guy.