He never specified the context that you were supposed to expect that caused the person to be labeled a Karen, since the actual context turned out to be unrelated to COVID. The only statement he was making was that a lot of people who refuse to wear masks have been Karens, not that everyone who refuses to wear them are Karens. As it turns out, I fully respect anyone's decision to not wear a mask if they're fully vaccinated. I don't consider them a Karen in that circumstance, but I still found the meme funny. A Karen is someone who raises a big stink about a minor perceived grievance or rule violation. And it's true; a lot of people raised a huge stink about being made to wear a mask, which is a mere inconvenience.