The electoral college vote and the popular vote have differed 5 times.
The first time was in 1824, in which all of the people running were Democratic Republicans. Andrew Jackson, who won the popular vote but came second in the electoral college, started the Democratic Party in protest of what he called a "corrupt bargain" that placed John Quincy Adams in the presidency.
The other four (1876, 1888, 2000, and 2016) all placed Republicans in the presidency while Democrats earned the popular vote.
But sure, it benefits all parties.