A little late, BUT
Saitama, firstly, has obviously done the mind blowing feats any anime character has done. He blew up a meteor the size of a skyscraper without breaking a sweat, he has easily bested some of the strongest beings in his world, he is somehow attractive to some of the hottest women on his planet, and, of course, has the ability to defeat ANY opponent in one punch.
Now, I hear you saying: "Nuh-uh, MYYYY OC wouldn't lose in one punch!!!1!", along with "But MYYYYYY OC can dodge it!!11!!!!".
Argument 1: Yes they would. That is what the writers of the Manga and Anime have said. You can't change what the writers say is canon. Simple as that.
Argument 2: Saitama can move at mind-shattering speeds. 122500000 mph to be exact. Now, about the characters like Overseer, or the obscure splatoon OC .Shiver. made like 2 years ago, he has a second ability. ZERO PUNCH. Saitama literally time travels, hitting so reality-breakingly fast, that there never was time to react. You cannot counter, block, or dodge, because there never was the time to.
Potential (still very unlikely) Losses: Edgyhead. Reality Bending powers could possibly confuse Saitama. The Tyrant. If he got the jump on Saitama, he might be able to deal some damage. Exotic Creator. Probably knows that he couldn't beat Saitama and wouldn't even fight him. Creatie and Tsar. Could possibly work together to partially weaken Saitama. The Imprisoned Titan. Could potentially consume Saitama if he got lucky.