On the first panel you see Hobbes following Calvin. Both characters are from: “Calvin and Hobbes” Calvin and Hobbes is a comic strip were this kid named Calvin has an imaginary friend which is a tiger named Hobbes (In real life the tiger is a stuffed animal) and the strip is about him being a kid with an having a huge imagination. On the second panel there is Winnie the Pooh following Christopher Robin. Those are characters from the famous book: “Winnie The Pooh”. In Winnie the Pooh is a kid named Christopher Robin. Christopher Robin pretends his stuffed animals are real people. The book is about all the adventures Christopher Robin imagines he gets in. The third and fourth panels show a teen Calvin and a teen Christopher Robin. In those panels Calvin and Christopher no longer play with Hobbes/Pooh. And then in the last panels Hobbes and Winnie start to realize they aren’t gonna play again so they are no longer imaginary friends. They are now stuffed animals.
Sorry for long comment.
