So here are some of the basics of meme etiquette...
If you comment on something upvote it
If somebody replies to your comment or comments on your meme upvote it
If you don't like a meme "downvote it or not" then move on and find one you like "flag" it only if it's offensive, otherwise just ignore it.
If you are being trolled, ignore it, we all have our moments where we just have to reply. You can try and be reasonable, if that fails ignore them. Don't mention their name or reply to their comments, even downvoting them can let them know they are getting to you. Ignore them and they have no power. Don't worry that fellow memers will take their side or believe them. Those of us that have been around know all about them, we won't support them, this is not a site where negativity is approved of or taken seriously.
There are many others, hopefully we can hear from different people and get their advice.