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But That's None Of My Business

But That's None Of My Business | ME WAITING FOR THE ALARM; BOTTOM TEXT | image tagged in memes,but that's none of my business,kermit the frog | made w/ Imgflip meme maker

by Skibble. in MS_memer_group

97 views, 3 upvotes

COCAINE (FROM FRENCH: COCAÏNE, FROM SPANISH: COCA, ULTIMATELY FROM QUECHUA: KÚKA)[14] IS A TROPANE ALKALOID THAT ACTS AS A CENTRAL NERVOUS SYSTEM (CNS) STIMULANT. AS AN EXTRACT, IT IS MAINLY USED RECREATIONALLY, AND OFTEN ILLEGALLY FOR ITS EUPHORIC AND REWARDING EFFECTS. IT IS ALSO USED IN MEDICINE BY INDIGENOUS SOUTH AMERICANS FOR VARIOUS PURPOSES AND RARELY, BUT MORE FORMALLY AS A LOCAL ANAESTHETIC BY MEDICAL PRACTITIONERS IN MORE DEVELOPED COUNTRIES. IT IS PRIMARILY OBTAINED FROM THE LEAVES OF TWO COCA SPECIES NATIVE TO SOUTH AMERICA: ERYTHROXYLUM COCA AND E. NOVOGRANATENSE.[15][16] AFTER EXTRACTION FROM THE PLANT, AND FURTHER PROCESSING INTO COCAINE HYDROCHLORIDE (POWDERED COCAINE), THE DRUG IS ADMINISTERED BY BEING EITHER SNORTED, APPLIED TOPICALLY TO THE MOUTH, OR DISSOLVED AND INJECTED INTO A VEIN. IT CAN ALSO THEN BE TURNED INTO FREE BASE FORM (TYPICALLY CRACK COCAINE), IN WHICH IT CAN BE HEATED UNTIL SUBLIMATED AND THEN THE VAPOURS CAN BE INHALED.[12]

COCAINE STIMULATES THE REWARD PATHWAY IN THE BRAIN.[16] MENTAL EFFECTS MAY INCLUDE AN INTENSE FEELING OF HAPPINESS, SEXUAL AROUSAL, LOSS OF CONTACT WITH REALITY, OR AGITATION.[12] PHYSICAL EFFECTS MAY INCLUDE A FAST HEART RATE, SWEATING, AND DILATED PUPILS.[12] HIGH DOSES CAN RESULT IN HIGH BLOOD PRESSURE OR HIGH BODY TEMPERATURE.[17] ONSET OF EFFECTS CAN BEGIN WITHIN SECONDS TO MINUTES OF USE, DEPENDING ON METHOD OF DELIVERY, AND CAN LAST BETWEEN FIVE AND NINETY MINUTES.[12] AS COCAINE ALSO HAS NUMBING AND BLOOD VESSEL CONSTRICTION PROPERTIES, IT IS OCCASIONALLY USED DURING SURGERY ON THE THROAT OR INSIDE OF THE NOSE TO CONTROL PAIN, BLEEDING, AND VOCAL CORD SPASM.[18]

COCAINE CROSSES THE BLOOD–BRAIN BARRIER VIA A PROTON-COUPLED ORGANIC CATION ANTIPORTER[19][20] AND (TO A LESSER EXTENT) VIA PASSIVE DIFFUSION ACROSS CELL MEMBRANES.[21] COCAINE BLOCKS THE DOPAMINE TRANSPORTER,[22] INHIBITING REUPTAKE OF DOPAMINE FROM THE SYNAPTIC CLEFT INTO THE PRE-SYNAPTIC AXON TERMINAL; THE HIGHER DOPAMINE LEVELS IN THE SYNAPTIC CLEFT INCREASE DOPAMINE RECEPTOR ACTIVATION IN THE POST-SYNAPTIC NEURON,[23][24] CAUSING EUPHORIA AND AROUSAL.[25] COCAINE ALSO BLOCKS THE SEROTONIN TRANSPORTER AND NOREPINEPHRINE TRANSPORTER, INHIBITING REUPTAKE OF SEROTONIN AND NOREPINEPHRINE FROM THE SYNAPTIC CLEFT INTO THE PRE-SYNAPTIC AXON TERMINAL AND INCREASING ACTIVATION OF SEROTONIN RECEPTORS AND NOREPINEPHRINE RECEPTORS IN THE POST-SYNAPTIC NEURON, CONTRIBUTING TO THE MENTAL AND PHYSICAL EFFECTS OF COCAINE EXPOSURE.[6]

A SINGLE DOSE OF COCAINE INDUCES TOLERANCE TO THE DRUG'S EFFECTS.[26] REPEATED USE IS LIKELY TO RESULT IN ADDICTION. ADDICTS WHO ABSTAIN FROM COCAINE MAY EXPERIENCE CRAVING AND DRUG WITHDRAWAL SYMPTOMS, WITH DEPRESSION, DECREASED LIBIDO, DECREASED ABILITY TO FEEL PLEASURE, AND FATIGUE BEING MOST COMMON.[16] USE OF COCAINE INCREASES THE OVERALL RISK OF DEATH, AND INTRAVENOUS USE POTENTIALLY INCREASES THE RISK OF TRAUMA AND INFECTIOUS DISEASES SUCH AS BLOOD INFECTIONS AND HIV THROUGH THE USE OF SHARED PARAPHERNALIA FOR USE. IT ALSO INCREASES RISK OF STROKE, HEART ATTACK, CARDIAC ARRHYTHMIA, LUNG INJURY (WHEN SMOKED), AND SUDDEN CARDIAC DEATH.[16][27] ILLICITLY SOLD COCAINE CAN BE ADULTERATED WITH FENTANYL, LOCAL ANESTHETICS, LEVAMISOLE, CORNSTARCH, QUININE, OR SUGAR, WHICH CAN RESULT IN ADDITIONAL TOXICITY.[28][29] IN 2017, THE GLOBAL BURDEN OF DISEASE STUDY FOUND THAT COCAINE USE CAUSED AROUND 7,300 DEATHS ANNUALLY.[30] | made w/ Imgflip meme maker

by Skibble. in MS_memer_group

67 views, 2 upvotes, 5 comments

Mocking Spongebob

Mocking Spongebob | gjyg15 after defending his attraction to yiff and piss fetish | image tagged in memes,mocking spongebob | made w/ Imgflip meme maker

by Skibble. in MS_memer_group

86 views, 2 upvotes, 7 comments

image tagged in cool user bingo | made w/ Imgflip meme maker

by Skibble. in MS_memer_group

63 views, 2 upvotes, 1 comment

ME FR | image tagged in cat in pinstripe | made w/ Imgflip meme maker

by Skibble. in MS_memer_group

93 views, 2 upvotes, 2 comments

by Skibble. in MS_memer_group

106 views, 2 upvotes, 2 comments

Stupid Invaders Fish

by Skibble. in MS_memer_group

110 views, 2 upvotes, 1 comment

by Skibble. in MS_memer_group

61 views, 2 upvotes, 2 comments

tck why?

by Skibble. in MS_memer_group

31 views, 2 upvotes, 3 comments

Uranus

by Skibble. in MS_memer_group

99 views, 3 upvotes

Idk

by Skibble. in MS_memer_group

111 views, 2 upvotes

by Skibble. in MS_memer_group

80 views, 2 upvotes, 1 comment

by Skibble. in MS_memer_group

81 views, 2 upvotes, 1 comment

do not eat the carpet

by Skibble. in MS_memer_group

68 views, 2 upvotes