Create
Make a Meme
Make a GIF or Short Video
Meme Templates
GIF Templates
All
All Streams
fun
gaming
repost
sports
reactiongifs
more streams ›
Hot
New
Sort By:
Hot
New
Top
past 24 hours
Top
past 7 days
Top
past 30 days
Top
March
Top
February
Top
January
Top
2026
Top
Dec. 2025
Top
Nov. 2025
Top
Oct. 2025
Top
Sep. 2025
Top
Aug. 2025
Top
July 2025
Top
June 2025
Top
May 2025
Top
Apr. 2025
Top
2025
Top
2024
Top
2023
Top
21st Century
more
NSFW
Skibble.
's Images
Make a meme
Make a gif
Imgflip Pro
AI creation tools & better GIFs
No ads
Custom 6x6 profile icon and new colors
Your images jump to the top of approval queues
Go Pro
by
Skibble.
in
MS_memer_group
76 views, 2 upvotes, 12 comments
share
Marked Safe From
by
Skibble.
in
MS_memer_group
81 views, 2 upvotes, 10 comments
share
by
Skibble.
in
MS_memer_group
61 views, 3 upvotes
share
But That's None Of My Business
by
Skibble.
in
MS_memer_group
100 views, 3 upvotes
share
SMALL RAIDS!! MORE FUN STREAM USERS!! MAYBE DOXXING!!
by
Skibble.
in
MS_memer_group
92 views, 2 upvotes, 1 comment
share
No it wasn't me, I play on xobx. Just thought I'd clarify
by
Skibble.
in
MS_memer_group
61 views, 2 upvotes, 1 comment
share
by
Skibble.
in
MS_memer_group
68 views, 2 upvotes, 7 comments
share
by
Skibble.
in
MS_memer_group
62 views, 2 upvotes, 22 comments
share
Laughing Leo
by
Skibble.
in
MS_memer_group
65 views, 2 upvotes, 17 comments
share
Always Has Been
by
Skibble.
in
MS_memer_group
95 views, 2 upvotes, 6 comments
share
by
Skibble.
in
MS_memer_group
62 views, 2 upvotes, 8 comments
share
by
Skibble.
in
MS_memer_group
64 views, 2 upvotes, 19 comments
share
Uranus
by
Skibble.
in
MS_memer_group
107 views, 3 upvotes
share
by
Skibble.
in
MS_memer_group
67 views, 2 upvotes, 5 comments
share
First
‹ Prev
Next ›
![COCAINE (FROM FRENCH: COCAÏNE, FROM SPANISH: COCA, ULTIMATELY FROM QUECHUA: KÚKA)[14] IS A TROPANE ALKALOID THAT ACTS AS A CENTRAL NERVOUS SYSTEM (CNS) STIMULANT. AS AN EXTRACT, IT IS MAINLY USED RECREATIONALLY, AND OFTEN ILLEGALLY FOR ITS EUPHORIC AND REWARDING EFFECTS. IT IS ALSO USED IN MEDICINE BY INDIGENOUS SOUTH AMERICANS FOR VARIOUS PURPOSES AND RARELY, BUT MORE FORMALLY AS A LOCAL ANAESTHETIC BY MEDICAL PRACTITIONERS IN MORE DEVELOPED COUNTRIES. IT IS PRIMARILY OBTAINED FROM THE LEAVES OF TWO COCA SPECIES NATIVE TO SOUTH AMERICA: ERYTHROXYLUM COCA AND E. NOVOGRANATENSE.[15][16] AFTER EXTRACTION FROM THE PLANT, AND FURTHER PROCESSING INTO COCAINE HYDROCHLORIDE (POWDERED COCAINE), THE DRUG IS ADMINISTERED BY BEING EITHER SNORTED, APPLIED TOPICALLY TO THE MOUTH, OR DISSOLVED AND INJECTED INTO A VEIN. IT CAN ALSO THEN BE TURNED INTO FREE BASE FORM (TYPICALLY CRACK COCAINE), IN WHICH IT CAN BE HEATED UNTIL SUBLIMATED AND THEN THE VAPOURS CAN BE INHALED.[12]
COCAINE STIMULATES THE REWARD PATHWAY IN THE BRAIN.[16] MENTAL EFFECTS MAY INCLUDE AN INTENSE FEELING OF HAPPINESS, SEXUAL AROUSAL, LOSS OF CONTACT WITH REALITY, OR AGITATION.[12] PHYSICAL EFFECTS MAY INCLUDE A FAST HEART RATE, SWEATING, AND DILATED PUPILS.[12] HIGH DOSES CAN RESULT IN HIGH BLOOD PRESSURE OR HIGH BODY TEMPERATURE.[17] ONSET OF EFFECTS CAN BEGIN WITHIN SECONDS TO MINUTES OF USE, DEPENDING ON METHOD OF DELIVERY, AND CAN LAST BETWEEN FIVE AND NINETY MINUTES.[12] AS COCAINE ALSO HAS NUMBING AND BLOOD VESSEL CONSTRICTION PROPERTIES, IT IS OCCASIONALLY USED DURING SURGERY ON THE THROAT OR INSIDE OF THE NOSE TO CONTROL PAIN, BLEEDING, AND VOCAL CORD SPASM.[18]
COCAINE CROSSES THE BLOOD–BRAIN BARRIER VIA A PROTON-COUPLED ORGANIC CATION ANTIPORTER[19][20] AND (TO A LESSER EXTENT) VIA PASSIVE DIFFUSION ACROSS CELL MEMBRANES.[21] COCAINE BLOCKS THE DOPAMINE TRANSPORTER,[22] INHIBITING REUPTAKE OF DOPAMINE FROM THE SYNAPTIC CLEFT INTO THE PRE-SYNAPTIC AXON TERMINAL; THE HIGHER DOPAMINE LEVELS IN THE SYNAPTIC CLEFT INCREASE DOPAMINE RECEPTOR ACTIVATION IN THE POST-SYNAPTIC NEURON,[23][24] CAUSING EUPHORIA AND AROUSAL.[25] COCAINE ALSO BLOCKS THE SEROTONIN TRANSPORTER AND NOREPINEPHRINE TRANSPORTER, INHIBITING REUPTAKE OF SEROTONIN AND NOREPINEPHRINE FROM THE SYNAPTIC CLEFT INTO THE PRE-SYNAPTIC AXON TERMINAL AND INCREASING ACTIVATION OF SEROTONIN RECEPTORS AND NOREPINEPHRINE RECEPTORS IN THE POST-SYNAPTIC NEURON, CONTRIBUTING TO THE MENTAL AND PHYSICAL EFFECTS OF COCAINE EXPOSURE.[6]
A SINGLE DOSE OF COCAINE INDUCES TOLERANCE TO THE DRUG'S EFFECTS.[26] REPEATED USE IS LIKELY TO RESULT IN ADDICTION. ADDICTS WHO ABSTAIN FROM COCAINE MAY EXPERIENCE CRAVING AND DRUG WITHDRAWAL SYMPTOMS, WITH DEPRESSION, DECREASED LIBIDO, DECREASED ABILITY TO FEEL PLEASURE, AND FATIGUE BEING MOST COMMON.[16] USE OF COCAINE INCREASES THE OVERALL RISK OF DEATH, AND INTRAVENOUS USE POTENTIALLY INCREASES THE RISK OF TRAUMA AND INFECTIOUS DISEASES SUCH AS BLOOD INFECTIONS AND HIV THROUGH THE USE OF SHARED PARAPHERNALIA FOR USE. IT ALSO INCREASES RISK OF STROKE, HEART ATTACK, CARDIAC ARRHYTHMIA, LUNG INJURY (WHEN SMOKED), AND SUDDEN CARDIAC DEATH.[16][27] ILLICITLY SOLD COCAINE CAN BE ADULTERATED WITH FENTANYL, LOCAL ANESTHETICS, LEVAMISOLE, CORNSTARCH, QUININE, OR SUGAR, WHICH CAN RESULT IN ADDITIONAL TOXICITY.[28][29] IN 2017, THE GLOBAL BURDEN OF DISEASE STUDY FOUND THAT COCAINE USE CAUSED AROUND 7,300 DEATHS ANNUALLY.[30] | made w/ Imgflip meme maker](http://i.imgflip.com/8542vb.jpg)
