If webcomics were to be turned into animated shows, Pixie & Brutus should definitely be one of them. It has a nice 'Slice Of Life' style premise with some comedy and the occasional serious subject mixed into it. There are especially a lot of cozy moments in the series that would be really nice to see animated. We could also get genuine lessons of friendship, empathy, acceptance, etc.
I can see it on a similar level as shows like Franklin, Little Bear, Arthur, Hey Arnold! and As Told By Ginger. And I really do think we need more of those shows today.