In slang, "doe" is a contraction for "though", often used at the end of a sentence, particularly in online or text-based communication, to express a concession or contrast, similar to saying "but" or "however". It is a common feature of informal American English, notably in the slang greeting "What up, doe!" from Detroit.
Examples of slang "doe"
"I don't like it, doe."
"This is pretty cool, doe."