I'd like to see Christopher Nolan make a sentient glob of oatmeal moving around with someone chasing it. That would be aweaome to see in live'action.

When the Mom blamed the dad for Calvin being a boy, I would have had him snap back "Oh, yeah? Prove it!" Then the mom walks away in a huff, and the dad thinks, "Well, she might not be able to prove it....but at least I'll have some peace."

That would be something to see. I would’ve loved to have seen a “Calvin & Hobbes” animated series at some point during the strip’s existence. That’s the main thing that I wish Bill Watterson would’ve allowed to be produced besides the main comic strip.