Black Ops III is my favorite singe-player campaign, and let me tell you why: The Cybercores, specifically Chaos Core.
I make RELIGIOUS use of the Sonic Anti-Personel Core Ability (if you don't know, it's a direct individual sonic barrage that causes a rather violent bout of nausea followed by fatal brain damage). With Sonic Anti-Personel, Riot Shield opponents become just another target for my fatal vomiting attack. Probably worse for Riot Shield guys because they wear enclosed helmets. Yikes.