On 16 April 2011, Gould revealed he had been diagnosed with acute lymphoblastic leukemia, a cancer of the white blood cells. It was his second diagnosis after a period of remission, having been previously diagnosed with the same illness on 30 January 2006. He posted a video on YouTube entitled "Edd vs Cancer" featuring himself, Ridgewell, and Hargreaves discussing the diagnosis. He platformed his illness for several sketches on his friends' YouTube accounts, and continued to animate Eddsworld while he was physically able.
Gould died from a recurring infection caused by the cancer on the morning of 25 March 2012.