DNA has been thoroughly mapped out. The science is settled on this one. You can change the hardware on your body, but your OS will always be what it was when you were born, just like your skeletal system. If Bruce Jenner or Sam Brinton committed a crime and left DNA evidence, law enforcement would say they’re looking for a male — not a transgender, not a female, not a non-binary, intersex (obviously behavior related rather than DNA).