Well, the Maus is already heavy as it is, but there are some ways,
Without any major overhauls, like majorly restructuring the interior of the tank, replacing the turret, reshaping the hull, etc, the Maus can be fitted with some fire control upgrades, like a laser rangefinder, wind sensor, thermal and infrared sensors, new munitions for it's 128mm cannon, etc, this can improve the firepower and accuracy of the tank with some sacrifices to mobility, however that's pretty much the limit to modernizing a Maus, it would still be deathly slow, made even worse by the addition of all the sensors, the turret is also still dead slow, and the armor is still ineffective, even against the earliest variants of T-64s or Leopard 2s.