You do know both the meme and the comment reference the Overlord DLC from Mass Effect 2, right? Also known as the one with the single most traumatized character in the game? Even more than the one you only meet if you go Colonist in Shepard's background? There's a cryptic modem noise some AI sends. Except it's not an AI. It's an autistic person hooked up to every transmission from every AI in the galaxy simultaneously. If you know what sensory overload is, imagine that, but an entire galaxy. It was a human making the noise the whole time. And it was not modem noise. It was a distress call. He was screaming for help. The noise was him screaming "Quiet! Please make it stop!" The one who did it to him is considered so evil that the PARAGON choice is to pistol whip the person who did that to him. If you pick the good choice, he is rescued and taken to an academy where Shepard states "they can help cases like him, minus the torture", also known as "ivy league school". Even Regenade Shepard is horrified by it.
The idea behind it is simple. The road to hell is paved with good intentions. Anyone who has played that DLC likely found the follow up in the next game cathartic, since you meet the person who is responsible for doing that to his brother, and you can lie and tell him he died. The one time in a game where every player unanimously considers "drive the bad guy to suicide even after he starts to feel remorse" the good option.
