The meme and gif are both from a South Park episode - which involved the school counselor, Mr Mackie (Mmmm' kay), and his personal experiences as both a promoter of abstinence - and then his subsequent experience with psychotropics.
Marijuana is a powerful medicine - with many beneficial applications and uses... And that can include getting "high". But like alll medicines - there can be a trade-off or balance between the desired effect - and other (side-)effects.
I was myself the actual creator (and relative to the show - character inspiration) for "Towelie". I say this, not to brag - but because it'z the actual facts, and history of my life.
I met Trey Parker and Matt Stone (South Park's Creators and Auteurs) at several parties in the Venice Beach area of California - in the early 1990's (very late 1980's?). At the time, I was in my early 20's (or perhaps 19) the first time that I had met them - at 48 - the timeline has become a little blurry, and considering the circumstances of our meetings - at parties - remarkable that I can remember much at all - but we both made impressions upon one another - and had some mutually beneficial interactions - the ripples of which have gone on to spread around the world - in amazing and (at the time) unpredictable ways. I had been experienced with 'the reefer' from a young age (and even some psychedelics - on a MUCH more limited basis, and later age - 16). Perhaps that was too young - I'll let those who tell my story, be the judges of the positives and negatives, of the undeniable facts.
I first tried weed at 12(7th grade). By 14 I was a fairly regular user - and as can be the case, particularly amongst the young folk who start 'using', in some ways I probably overindulged - to the point of consequences.
In the 8th grade(9th?) my best friend at the time (and later the co-creator of the "Towelie", and the phrase "Hey Kids - any body wanna' GET HIGH" (said in the high voice of a cartoonish character like "Towelie") and I got kicked out of "The Windward School" together - for a Quarter - for coming back to Campus (after school) after "smoking-out" in an alley nearby. (Some old lady had called the school - and told them what she saw - and gave them a description). When we got back to campus a few minutes later, we were singing a rather funny song, and laughing... And we might have even "reeked" a little bit, though I believe we'd taken some precautions (visine/breath drops, gum). They split us up immediately (tbc)