Endocrine disruption is a real thing. I could post a wall of PubMed medical references to it. And that line in Jurassic Park about frogs changing sex is real too. Adding an endocrine disrupting chemical to a frog that already has weird genetics can easily cause them to get all gender-bent.
I expect this sort of post on 9gag, which is just a wannabe /r/4chan, but I expect better from Imgflip.