REMEMBER: Anything you UPLOAD is NOT considered a TEMPLATE--even if you started with one of the standard templates. So with the "change, save, upload" cycle the end result will be considered a ONE-OF-A-KIND meme.
You WON'T get the benefit of people looking through "Other captions for this template", finding YOUR meme and upvoting it.
So if you're using a standard template, before using the "multi-font" technique, decide whether multiple fonts is worth having fewer views and possible upvotes.