Y U no can do science?
Positrons are indeed antimatter particles. Too many of them can be lethal. PET (anti-matter) scans use them.
I interpreted Data's positronic circuitry to mean something analogous to regular electronic circuity, except with positrons (anti-electrons) moving through them rather than normal electrons. If that is the case, he is potentially very dangerous. Positron annihilation releases gamma rays.
For positrons to operate in a material circuit in a manner analogous to regular electrons in a circuit, the entire circuit would have to be made of antimatter to prevent their instant annihilation.
positrons + electrons go boom! - make many gamma ray babies that run amok!
I don't know if he would explode or not, but an antielectric circuit would respond violently to contact with outside regular matter if we broke into it. Data would invoke a lot of nasty multilingual contractions if that happened!
positron + electron = e = mc²
It's da twuth!