This gif is from the final scene of Avengers: Infinity War, where Thanos goes to his farmhouse planet after he finally achieved his goal of collecting the Infinity Stones and erasing half of all life in the universe.
This gif can be used in a meme in which a character has put up with something for the longest time and is now glad and graceful for the fact that they no longer have to deal with that annoyance for as long as they live.
