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The first recorded smallpox outbreak in Hispaniola occurred in December 1518 or January 1519. The 1518 smallpox epidemic killed 90% of the natives who had not already perished. https://tainomuseum.org/taino/ Lacking immunity to Old World pathogens carried by the Spanish, Hispaniola’s indigenous inhabitants fell victim to terrible plagues of smallpox, influenza, and other viruses. Columbus built his first town on the nearby island of Hispaniola, where the Taino numbered at least 60,000 and possibly as many