Franky Fork literally kills Satan and seeks vengeance towards the crew. He was responsible for putting hate into dictators to murder millions. All he wants is to make the crew suffer.
Now that's the most OP villain but what about good guys you say?
The most powerful being is Beth-Ruth. A blob girl that can consume anything and grow into the size of Earth. A metaphorical walking grinder. She can break down anything in her body. No indigestion to kill her. The only thing that can kill her is the cold hence why she stays out of the cold areas
