Regeneration and Immortality: The Immortal Hulk is known for practically limitless regeneration, often returning from complete destruction of his body. V1 relies on absorbing blood to repair itself, but it would have no way to permanently kill or stop the Hulk, especially when the Hulk can get stronger the angrier he gets.
Power Scaling: V1 is designed to fight in the "meat" industry of hell and battles powerful entities like Gabriel, but its feats do not reach the level of durability needed to survive the Hulk, who can trade blows with gods, destroy planets, and survive nukes.
Speed vs. Durability: While V1 is extremely fast (able to dash and slide around combatants), it is still a "murderous security camera". V1 is vulnerable to intense firepower; it would likely get destroyed by the immense physical force and durability the Hulk possesses.
In summary, V1 might annoy or injure the Hulk, but it lacks the necessary power to overcome the Immortal Hulk's regeneration and durability.
