Billy and Stu vs James Bond and John Wick, who wins?

The Scream guys are strong, but they aren’t disciplined or trained, so I think Bond would go for Stu and Wick would go for Loomis and Wick + Bond would win

Well, they are experienced killers with an extremely high body count who inadvertently (maybe? idk, Stu apparently survived the TV falling on him and is returning in the next movie) started a string of serial killers murdering TONS of people over the span of several years
Generational killers and true masterminds

Yeah, but Bond is implicitly ex military (as Vesper said, “former SAS types with easy smiles and expensive watches”) and Wick has been a trained hitman for decades. Also, Billy and Stu only have a knife each and that Beretta, but Bond has his Walther/Sig Sauer and Wick has literally hundreds of thousands of dollars worth of guns to choose from and can afford to buy a new one at any time.

Technically, Billy and Stu have whatever they can pick up off a victim
so they could steal a gun
and besides, if they cath Bond or Wick off guard, they won't have time to get their fancy weaponry while trapped

Good point. I think it would come down to Wick’s ability to go in alone and disarm multiple attackers at once, then Bond coming in as backup once Billy and Stu are in sight

You assume that they'd be in the same area at the same time
Since people think there's only one killer, all one of them would need to do is do serious enough damage to one opponent to possibly kill them if they're not treated properly, and even if that Ghostface dies, the other could take out whichever of Bond and Wick are living or less wounded, or even just would them seriously enough to kill them both off while they're weak

Wick clears a room like a Navy SEAL or a Delta Force operator though, and he’s quick with a gun. If Billy and Stu have no advance notice, Wick could take one of them by surprise and shoot them as they round a corner, bloody knife in hand. Meanwhile Bond would provide cover fire and backup, taking over combat once Bond and Wick have figured out who the killers are and have cornered them.

Depends
is it an organized fight, a brawl, or what?
what's the location?
What are their weapons?
What's the situation?

What’s the most plausible? Possibly the US requests Bond’s help with the violence in Woodsboro, and the CIA hires John Wick for backup. So maybe Billy and Stu are set up and attacked but they’re armed and alert, maybe it’s post-reveal, and Bond and Wick usher Sidney and any other survivors at that point out of the house and engage Billy and Stu in a fight.

well, if Billy and Stu have the upper hand and are in that first situation, it's an easy win for them
think about it, even with training, good weapons, and strategy, they're still going up against two unknown experienced serial killers who are assumed to be one person, and on their home turf.
Billy and Stu also are good at coordinating attacks and killing creatively in many situations, and this versatility in high stakes situations with low regard for their personal safety means they'd be free to lure and trap the two in an enclosed space and lead them off separately from each other and kill them, being able to both focus on one opponent together while the other searches for them

Maybe Bond would be worse off, but John Wick took out that whole hit squad, mostly at close quarters/grappling, in his home. So Bond might die/be seriously hurt if he’s not careful, but even Billy and Stu are probably no match for the Baba Yaga. Especially because Wick is good with BJJ and once Wick figures out why they’re doing what they’re doing, he’ll have no mercy on them.

yeah, but they have the advantage of planning their locations ahead, and knowing the area better
So the ghostfaces could attack from a longer range without being caught
Like if they shot at wick or bond from a secure location within a building they're trapping them in
Or if they do a JFK