British Medical Journal in March 2024 found that women who took Depo-Provera had a 500 percent higher risk of developing a meningioma (a tumor that specifically forms and develops in the membranes around the brain and spinal cord) than women who did not get the shot that women across the world realized the connection.
A February 2025 study purported to confirm that the chemical compound that makes up Depo-Provera increases the risk of meningioma in women who take it.