Sometimes it is pests in walls, a piece of dust, tiny bug or spider, their own insanity and in personal experience it can be paranormal although negative behavior positions, growling, spitting, hissing etc tends to follow or they run away. Saw a dog in my friend's grandma's house near Parkersburg WV when I was near 14 sit up in the middle of the room growling at nothing and the cat they had wouldn't even enter the house. Safe to say we left the house because it was creepy. So not impossible to be seeing that but usually is followed by behavior, avoidance of room or home or hiding.