I used a lot of contradicting ones… I think I used:
Really Bad Time
Key Key Key Key
Battle of Wits
Rent’s Due
I’m Running Here
Rush Hour
Afterimage
Out of Stuff
El Goblino’s Payday
Roundabout
Bad Electrical Work
Itchy
Rent’s Due and Afterimage counteract Rush and Ambush being faster
Key Key Key Key counteracts battle of wits because in a room with no drawers, the key always spawns in front of the correct door
Out of Stuff and El Goblino’s Payday counteract Itchy because you don’t have to open drawers (not even batteries will spawn, so use any light source wisely)
Bad Electrical Work and Roundabout are just easy
Everybody’s experience will be different, but this is the combination I found the easiest. It gets you to 150% without affecting speed, health, the Seek chases, or the Figure stealth sequences. Granted, you will have to get Not Five Stars for some of these modifiers, but doing so will make it infinitely easier. Just do a similar thing and choose modifiers that counteract each other.