Quoted from SFriedRice on reddit:
"This meme is referring to Ironmouse, a female Vtuber on twitch who won the award for Content Creator of the year. She suffers from an illness called 'Common Variable Immunodeficiency' (CVID) which means her immune system is really weak and that she could get sick or infected very easily and, in worst case scenario, die.
Because of this she was kept indoors, mostlty bedridden, and isolated. She was understandably lonely and yearned for friends. Because of this she started a career as streamer.
“I was watching so many people have fun playing games and talking to their friends on stream, and I was like, 'Man, I really want to do that.'""
