Considering Cosmo is canonically god, and also according to the lore, this would imply that Caleb was a witness to Cosmo's life, meaning Caleb (lore-wise) would also have been witness to the Tragedies, and suffered a lot of damage to his physical body. Working this image and Caleb into the lore, this implies that upon Cosmo's death (and randomly becoming god) Caleb died of a heart attack shortly after Cosmo's death.
