I'd probably trust Mothermind with my drink. She's JUST an ai anyway.
Cake? Hell no. I wouldn’t trust her with anything.
Agatha? Maybe. There is a 30% chance she'll poison it, though.
Larry? He's not really a villain, but he works for one. And yeah, I would. He's a little baby boy who wouldn't do anything.
Nicolas? No, he WOULD poison it.
And that's all I can think of for now. :3