The best way to get points and get them quickly is to comment on front page memes and the memes in "latest." Once you get to 1,000 points, you'll be able to meme comments and then you can post even better comments. And like forceful already said, upvote the memes you comment on. I would go further to say upvote the memes you comment on, even if the memes aren't all that funny. It'll still look good on you and the bigger users will start to notice this. And also, upvote all the comments you comment on. It's good form here.
And also, take it from me, don't get into political arguments. I do from time to time and it can get old quick. And you might make enemies that way.
Just have fun! It's worth it if you just take everything here with a grain of salt. Remember, this is a meme site and nothing is worth getting upset over. You'll start to get to know the bigger users (the top point getters and those who frequent the site often) and start establishing yourself. The points will come and the funny conversations will begin.
