Both are creatures in Cherokee Indian mythology.
The Uktena was a gigantic, antlered serpent with a gem in its forehead. It could also spit corrosive venom which, if it hits your skin, will cause a tiny snake to grow from the spot the venom touched.
According to legend, a medicine man was captured by the Cherokee once. The medicine man said that if the Cherokee let him go, he would get the Uktena's gem. They let him go, and he eventually found the Uktena. He made a barrier of fire to protect himself from the venom, then shot at the seventh spot back from the Uktena's head (where its heart is) and killed it.