This comic is in reference to laws effectuated by the Export Administration Act. Among other things, the law prohibits "agreements to refuse or actual refusal to do business with or in Israel" by US citizens and businesses. Penalties for each transgression can be quite severe: "each 'knowing' violation can be a fine of up to $50,000 or five times the value of the exports involved, whichever is greater, and imprisonment of up to five years."