Ethan Winters
Got his wife kidnapped, got murdered trying to get her back, got resurrected by an infection, got his arm and his leg cut off as well as get stabbed and injured multiple times, but due to his infection he can reattach his limbs with some healing ointment. Finally got his wife back
A year or two later, they have a baby, wife gets kidnapped again, baby is taken and later finds out her body parts were cut off and put in flasks, yet is somehow able to get her back. While he's there, gets his hand cut off, again, gets some of his fingers bitten off, gets a bite taken out of his wrist, gets stabbed and beaten, like usual. He then gets his literal heart ripped out, dies, comes back due to the infection, finally gets his daughter and his wife back, and sacrifices himself to blow up the source of the infection, because it's the reason why almost everything and everyone wants to kill him, and finally dies.