343 BC Battle of Mount Gaurus Roman general Marcus Valerius Corvus defeats the Samnites.
Battle of Suessula The Roman Republic beats the Samnites, but is forced to withdraw due to the revolt of several of its Latin allies.
Battle of Pelusium Persians defeat Egyptian forces under Nectanebo II.
342 BC Battle of Maling Tian Ji and Sun Bin of Qi again defeat Pang Juan of Wei, this time at Dazhangija Town, Shen County, in Henan Province.
340 BC Battle of the Crimissus Timoleon defeats the Carthaginian invaders of Sicily.
Siege of Byzantium A siege by Philip II of Macedonia.
339 BC Battle of Vesuvius Romans under P. Decius Mus and T. Manlius Imperiosus defeat the rebellious Latins.
Battle of the Crimissus Syracue under Timoleon defeats Carthage.
338 BC Battle of Chaeronea 2 August - Philip of Macedon crushes Athens and Thebes in their struggle to maintain their independence.
Battle of Trifanum Roman general T. Manlius Imperiosus decisively defeats the Latins.
Battle of Manduria Sparta and its colony Taras both defeated by the Brutian League in front of the walls of Manduria. Spartan king Archidamus III killed.
335 BC Siege of Pelium Macedon under Alexander the Great defeats the Illyrians
Battle of Thebes Macedon under Alexander the Great defeats Thebes and razes the city.
334 BC Battle of the Granicus Alexander the Great defeats the Persian army in Western Asia Minor.
Siege of Miletus Macedon takes Miletus from Persia
Siege of Halicarnassus Alexander the Great takes Halicarnassus
333 BC Battle of Issus Alexander the Great defeats the main Persian army under King Darius III in northern Syria.
Siege of Gordium Parmenion, in the absence of Alexander, captures the city of Gordium from the Persian Achaemenid Empire, annexing all Anatolia to Macedon.
332 BC Siege of Tyre (332 BC) Alexander the Great besieges the city.
Siege of Gaza Alexander the Great, commander of the Macedonian forces and their Greek allies, takes Gaza from the Persian Batis, gaining Egypt.
331 BC Battle of Pandosia Alexander of Epirus, the uncle of Alexander the Great, is defeated and killed in Italy by the Samnites.
Battle of Megalopolis Antipater, Alexander's regent in Macedon and Greece, defeats the Spartans under King Agis III.
Battle of Gaugamela 1 October - Alexander the Great defeats Darius III in Mesopotamia and conquers Persia.
Battle of the Uxian Defile December - Alexander the Great defeats the Uxii tribes of the Zagros Mountains.