1346 is the worst... The deadliest of them all started. The black plague started in 1346. Covid 19 will NEVER reach the numbers that the black plague did. The black plague is so strong that even though it died in 1353, It came back as the real final boss of 2020 in China. It's a bit weaker than it used to be but, it's still strong. in the fourteenth century, it killed about 350-375 million people which, I don't know the exact population in 1346 but I am guessing about half of the population of earth.