I'll give you some tips:
1) Pick some good characters, about 5-7 of them so the audience doesn't get bored of seeing the same ones everytime.
2) Try to make your content original, you can get some inspiration from others but you can't copy it completly.
3) Try to make it relatable or funny, or it might not make any sense at all.
4) Pick a good name, that's what will stand out against other comic strips.
5) Always stick to a format, either 3 panels or 4.