Meme often. Try to think of original stuff, but don't beat yourself up too much over it. Take lots of notes when you're out and about on what you find amusing. Don't be afraid to try out new material. Don't be afraid to put a new twist on an old idea.
Go after genders all you want, go after canada/healthcare all you want but be prepared to get bombarded with apologists. Nobody ever talks about abortion, but torture is always fun, especially waterboarding. One of my favorites!
Stay away from Christianity and guns because we've literally heard it all and people are so beyond closed minded you can have a 12-day argument with them for them to drop off the radar when you get them nailed down.
I guess that's the short list. :-)
Caption this Meme
