Once you hit a comment timer, open another tab. It let's you catch up on replies, work a second (or third or fourth depending on how many windows you want to have open and manage) meme. Once you've made dent in your replies or the other meme pages you can go back to the original meme. It's better than just sitting there for almost 3 minutes waiting on a stupid timer.
Side rant: If it's your own meme, and you're replying to responses on a meme you submitted, you shouldn't have a comment timer at all.